Abstract
The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested.
Highlights
The cellular surface is covered with different receptors, that mediate several recognition events in living systems through carbohydrate–protein, protein–protein, or antigen–antibody interactions [1].Particular interest is devoted to carbohydrate-recognition proteins, termed lectins, that can recognize carbohydrates and participate in different biological events, namely cell–cell adhesion, cell–cell recognition and cell differentiation
Results showed that coatings containing only AM groups promoted viral adhesion (Figure 9, (iii)), which could be suppressed by the addition of thick and dense glycopolymer brushes to the coating (Figure 9, (iv)), forming a steric and hydration repulsion barrier
Structures of antiviral glycopolymer brushes prepared by combination chemical
Summary
The cellular surface is covered with different receptors, that mediate several recognition events in living systems through carbohydrate–protein, protein–protein, or antigen–antibody interactions [1]. 2. Preparation of Polymer Brushes by RDRP of the materials is described, highlighting the importance of these materials, especially in the Polymer biomedical field.brushes are densely grafted polymers that can be found attached to several solid surfaces [19] or in their free form, known as bottlebrushes [20,21]. Preparation of Polymer Brushes by RDRP of the materials is described, highlighting the importance of these materials, especially in the Polymer biomedical field.brushes are densely grafted polymers that can be found attached to several solid surfaces [19] or in their free form, known as bottlebrushes [20,21] These polymers can be prepared using methods mainly three strategies, “grafting to”, “grafting from”, and “grafting
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