Abstract
Glycine microinjection into the substantia nigra zona compacta (SNC) in lightly anesthetized rats produced a marked and rapid decrease in spontaneous discharges of SNC neurons and a simultaneous enhancement of caudate nucleus (CN) activities. In animals pretreated with the dopamine receptor blocker, haloperidol, intranigral microinjection of glycine produced a dissociation of the nigral inhibition and caudate excitation. The SNC neurons were similarly suppresed with the CN neurons exhibited no discernible changes in firing frequency. A possible role was suggedted fro glycine as an inhibitory neurotransmitter acting on the cells of origin of the nigrostriatal pathway.
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