Abstract
BACKGROUND:Essential hypertension is a complex genetic trait. Genetic variant of alpha adducin (ADD1) gene have been implicated as a risk factor for hypertension. Given its clinical significance, we investigated the association between ADD1 Gly460Trp gene polymorphism and essential hypertension in an Indian population. Further, a meta-analysis was carried out to estimate the risk of hypertension.METHODS:In the current study, 432 hypertensive cases and 461 healthy controls were genotyped for the Gly460Trp ADD1 gene polymorphism. Genotyping was determined by real time PCR using Taqman assay. Multiple logistic regression analysis was used to detect the association between Gly460Trp polymorphism and hypertension.RESULTS:No significant association was found in the genotype and allele distribution of Gly460Trp polymorphism with hypertension in our study. A total of 15 case-control studies were included in the meta-analysis. There was no evidence of the association of Gly460Trp polymorphism with hypertension in general or in any of the sub group.CONCLUSIONS:We found that the Gly460Trp polymorphism is not a risk factor for essential hypertension in a south Indian Tamilian population. However, the role of ADD1 polymorphism may not be excluded by a negative association study. Further, large and rigorous case-control studies that investigate gene–gene–environment interactions may generate more conclusive claims about the molecular genetics of hypertension.
Highlights
Essential hypertension is a highly prevalent, complex, multifactorial disorder that arises from the interaction of genetic predisposition and environmental risk factors
The recent epidemiological investigation on Indian population has shown that the incidence of cardiac events and cardiac mortality would be doubled by the year 2020
In India, hypertension directly accounts for about 57% of stroke and 27% of CAD deaths.[56]
Summary
Essential hypertension is a highly prevalent, complex, multifactorial disorder that arises from the interaction of genetic predisposition and environmental risk factors. It is significantly associated with the pathophysiology of cardiovascular disorders such as myocardial infarction, stroke, and coronary artery disease. We investigated the association between ADD1 Gly460Trp gene polymorphism and essential hypertension in an Indian population. METHODS: In the current study, 432 hypertensive cases and 461 healthy controls were genotyped for the Gly460Trp ADD1 gene polymorphism. CONCLUSIONS: We found that the Gly460Trp polymorphism is not a risk factor for essential hypertension in a south Indian Tamilian population. Large and rigorous casecontrol studies that investigate gene–gene–environment interactions may generate more conclusive claims about the molecular genetics of hypertension
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
