Abstract
BackgroundAngiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Ample association studies have reported the importance of AGT variants in cardiovascular and non-cardiovascular adversities. But lately, owing to the complexity of the many anomalies, the haplotype based examination of genetic variation that facilitates the identification of polymorphic sites which are located in the vicinity of the causative polymorphic site, gets greater appreciation.MethodsIn the present study, we have done genotype and haplotype analysis of AGT gene in reference to hypertension to confirm the association of the two in an Indian population. To accomplish this, we performed candidate SNPs analysis and construct possible haplotypes across the AGT promoter and gene region in 414 subjects (256 Hypertensive cases and 158 controls).ResultsWe found four SNPs (rs11568020: A-152G and rs5050: A-20C in promoter; rs4762 and rs699 in exon2) and 3 haplotypes (H4, H7 and H8) that showed a stronger positive association with hypertension. The haplotype H2 was showing protective association with hypertension.ConclusionThe results of the present study confirmed and reestablished the role of AGT gene variants and their haplotypes in the causation of hypertension in Indian population and showed that haplotypes can provide stronger evidence of association.
Highlights
Angiotensinogen (AGT) enzyme comprises a vital module of Renin-Angiotensin-Aldosterone System (RAAS) system that effectively controls the blood pressure and related cardiovascular functions
The mean age, blood pressure, low density lipoprotein cholesterol (LDL), Uric acid, Urea, BUN, chloride, glucose and cholesterol in Hypertensive group were significantly higher than Normotensive group
Over the past few decades, tremendous efforts have been made to solve the complexity of disorders like hypertension
Summary
Angiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Hypertension (HTN) is a chronic medical condition in which the blood pressure in the arteries is increased It is one of the most common and complex human diseases that cause significant heart failure, renal failure, ventricular arrhythmias, blindness and other serious medical problems [1, 2]. It is a common risk factor for cardiovascular morbidities like stroke, atherosclerosis and myocardial infarction. For a complex trait the susceptible gene(s) are searched by genetic-association studies These studies look for deviations from the random occurrence of the alleles with respect to disease phenotype which results in significant increase or decrease in their frequency. SNP analysis is pretty widely used for the disorder with single
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
