Abstract
BackgroundGlutathione (GSH) protects against oxidative stress by combating reactive oxygen species (ROS) generation.ObjectiveThis study aimed to investigate the protective effects of GSH against azoxymethane (AOM) ‐ induced colon cancer in rats.Methods40 Sprague‐Dawley rats were divided into 4 groups (10 rats per group), control group, GSH‐fed group, AOM‐injected group, and GSH‐fed/AOM‐injected group. Animals were continuously fed ad‐libitum their specific basal or GSH‐diets for 16 weeks. At the end of the experiment, all rats were sacrificed and the colon tissues were examined microscopically for lesions suspected of being tumors as well as for biochemical measurements of oxidative stress indices.FindingsThe results revealed a lower incidence of aberrant crypt foci in GSH‐fed/ AOM‐injected group as compared to AOM‐injected group. GSH augmented the AOM‐induced glutathione depletion and antioxidant enzymes inhibition in the examined colon tissues.ConclusionThe results obtained suggest that GSH inhibits the development of colonic premalignant lesions in an experimental AOM‐induced colon carcinogenesis model, at least in part, by abrogating oxidative stress and improving redox status of colonic cells.
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