Abstract
The γ-glutamyl transpeptidase (EC 2.3.2.2) activity of the urine was determined in 369 cases, with l -γ- glutamyl-p- nitranilide as substrate. Thermally stable, low molecular mass inhibitors were removed by dialysis. The enzyme activity was found to have a mean of 10.57 U/1 for the normal neonate population, and a mean of 16.92 U/1 for children. A significant increase in activity was observed in pyelonephritis, Alport's syndrome, Wilms' tumour and glomerulopathies. The highest activities were found in kidney diseases associated with renal insufficiency. This non-invasive test can be used for the evaluation of tubular disorders in childhood.
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