Glucose-mediated glucose disappearance during the intravenous glucose tolerance test: evaluation of the minimal model of glucose kinetics

Abstract

In order to directly measure glucose-mediated effects on glucose disappearance, intravenous glucose tolerance tests were performed in insulin-dependent diabetic subjects without dynamic insulin response after glucose administration. Two models, the minimal model of unlabeled glucose kinetics and a linear two-compartment model, were identified from glucose data. The performances of those two models were compared on the basis of goodness-of-fit criteria and of practical identifiability. The results suggest the inadequacy of the the minimal model to describe glucose-mediated glucose disappearance after glucose administration. The considered two-compartment model seems to be sufficiently complex to account for the observed glucose-mediated glucose dynamics.