Abstract
Saccharides - a versatile class of biologically important molecules - are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose.
Highlights
Glucose is a universal nutrient preferred by most organisms and serves fundamental roles in energy supply,[1] carbon storage,[2] biosynthesis and cell wall formation.[3]
In humans, the aberrant control of glucose metabolism leads to the condition of Diabetes Mellitus, a chronic and potentially debilitating disease which, it is estimated, currently affects 2.8% of the global population; a gure expected to rise to 4.4% by 2030.4 Delayed detection and/or control of blood glucose in suffers is correlated with poor clinical outcomes and increased risk of comorbidities
The advancing contact angle for bis-boronic acid (bis-BA) self-assembled monolayer (SAM) was in good agreement with the literature for pyrene-terminated monolayers,[19] noting that the hysteresis value of 7 suggests the presence of a packed monolayer
Summary
Glucose is a universal nutrient preferred by most organisms and serves fundamental roles in energy supply,[1] carbon storage,[2] biosynthesis and cell wall formation.[3]. Mixed SAMs of different solution concentration ratios of bis-BA and TEGT (1 : 1, 1 : 5, 1 : 10 and 1 : 40) were formed for 24 hours and analysed by contact angle.
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