Abstract
BackgroundSelenium (Se) is an essential element in the human body that plays an important role in numerous fundamental physiological functions. However, the distribution of Se in the environment varies widely resulting in this element being available in a large concentration range in the ecosystem, and thus, in the human body. Urinary Se is a biomarker considered to be involved in adaptive mechanisms that help prevent health problems. ObjectivesThe purpose of the present study was to conduct a systematic review to identify studies reporting the status of urinary Se in healthy children and create a global map. MethodsA literature search was conducted using MEDLINE (United States National Library of Medicine), Web of Science, Toxicology Bibliographic Information (TOXLINE), Latin-American and Caribbean Literature on Health Sciences (LILACS), and the grey literature. This study was registered in PROSPERO (international prospective register of systematic reviews) and was conducted in accordance with the PRISMA guidelines. ResultsWe identified 322 relevant articles, out of which 15 were included in this systematic review. The study identified a total of 4038 healthy children worldwide with urinary Se concentrations from 7.7 to 145.0 μg/L. ConclusionThis is a pioneering study that provides evidence for the presence of Se in the urine of healthy children; we have shown that the available data is restricted to a small number of individuals and specific groups. Furthermore, there is a lack of information on urinary Se, especially in Latin America, Africa, and Asia.
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