Global research trends in liquid biopsy for ovarian cancer from 1999 to 2023: A 25-year bibliometric analysis

Abstract

BackgroundOvarian cancer (OC) is a major cause of gynecological cancer-related death in the world. Liquid biopsy has shown great potential in improving the ovarian cancer detection and treatment. The aim of this study is to explore the previous studies, current hotspots, and future trends of liquid biopsy for OC from a bibliometric perspective. MethodsArticles on liquid biopsy in the field of OC were collected from Web of Science (Clarivate Analytics). Subsequently, bibliometric and visual analyses was conducted using bibliometrix, VOSviewer, CiteSpace, and Microsoft Excel. ResultsA total of 504 scientific papers were retrieved over a 25-year period, of which 285 papers were in the language of English. China has the highest number and other papers came from 41 countries or regions. The journal with the highest publication count was Cancers. There were 2013 authors in total, and Kasimir-Bauer S emerged as the most productive author. The key words that are still exploding are recurrence, predictive value and survival. ConclusionResearch on liquid biopsy is booming in the field of OC. This article comprehensively elucidates the subject matter over recent years, and points out emerging trends for in-depth exploration.