Abstract
In response to pressure overload the left ventricle (LV) remodels to compensate for the increased workload. Initially this adaptation is beneficial to maintain pump function, but eventually the heart may loose its battle to cope with the increased workload resulting in heart failure (HF). In this study the evolution of global LV function was characterized in a relevant mouse model of LV pressure overload during the development of HF using MRI.
Highlights
In response to pressure overload the left ventricle (LV) remodels to compensate for the increased workload. This adaptation is beneficial to maintain pump function, but eventually the heart may loose its battle to cope with the increased workload resulting in heart failure (HF)
In this study the evolution of global LV function was characterized in a relevant mouse model of LV pressure overload during the development of HF using MRI
In this group suggests that these animals develop end stage heart failure
Summary
In response to pressure overload the left ventricle (LV) remodels to compensate for the increased workload. This adaptation is beneficial to maintain pump function, but eventually the heart may loose its battle to cope with the increased workload resulting in heart failure (HF).
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