Abstract
Background: Intermediate frequency magnetic fields (IF-MFs) at around 85 kHz are a component of wireless power transfer systems used for charging electrical vehicles. However, limited data exist on the potential health effects of IF-MFs. We performed a comprehensive analysis of transcriptional expression in mice after IF-MF exposure. Materials and Methods: We developed an IF-MF exposure system to generate a high magnetic flux density (25.3 mT). The system can expose the IF-MF for a mouse whole-body without considering thermal effects. After 10 days (1 h/day) of exposure, a comprehensive expression analysis was performed using microarray data from both the brain and liver. Results: No significant differences in transcriptional expression were detected in the 35,240 probe-sets when controlling the false discovery rate (FDR) under a fold change cutoff >1.5. However, several differential expressions were detected without FDR-adjustment, but these were not confirmed by RT-PCR analysis. Conclusions: To our knowledge, this is the first in vivo study to evaluate the biological effects of IF-MF exposure with an intense magnetic flux density 253 times higher than the occupational restriction level defined by the International Commission on Non-Ionizing Radiation Protection guidelines. However, our findings indicate that transcriptional responses in the living body are not affected under these conditions.
Highlights
Wireless power transfer (WPT) systems are based on magnetic resonance, and electromagnetic induction methods are expected to be commonly used for charging electric vehicles using intermediate frequency magnetic fields (IF-MFs), including 85 kHz bands
To suppress any thermal effects during Intermediate frequency magnetic fields (IF-MFs) exposure, the temperature around the top of the acrylic holder containing the mice was measured with the fiber optic thermometer, regulated to 24 ◦ C ± 0.5 ◦ C under both 90A_exposure and sham-exposure groups
The optimum temperature to rear a mouse is between 21 ◦ C and 25 ◦ C; we decided to perform in vivo exposure experiments at 90A corresponding to 25.3 mT of the magnetic flux density
Summary
Wireless power transfer (WPT) systems are based on magnetic resonance, and electromagnetic induction methods are expected to be commonly used for charging electric vehicles using intermediate frequency magnetic fields (IF-MFs), including 85 kHz bands. To achieve early widespread use of WPT systems, obtaining data on the possible biological effects of IF-MF exposure around 85 kHz bands is needed, from in vivo studies. Microarray analysis is one appropriate method for exploring biological reactions that depend on changes in genome-wide expression associated with health and disease. Intermediate frequency magnetic fields (IF-MFs) at around 85 kHz are a component of wireless power transfer systems used for charging electrical vehicles. Limited data exist on the potential health effects of IF-MFs. We performed a comprehensive analysis of transcriptional expression in mice after IF-MF exposure. Results: No significant differences in transcriptional expression were detected in the 35,240 probe-sets when controlling the false discovery rate (FDR) under a fold change cutoff
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