Abstract

A GLC method for determining sorbitol in aqueous irrigating solutions is described which has advantages over the USP adsorption column chromatography procedure. It is based on a reported method using the hexaacetate derivative. Samples are chromatographed on a trifluoropropyl silicone on a support of silanized, flux-calcined diatomite. Bis(2-ethylhexyl) sebacate serves as the internal standard. Mannitol and other polyhydric alcohols do not interfere and may be determined concomitantly if desired. The GLC method is recommended for consideration as a replacement for the USP procedure.

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