Abstract
IntroductionThe Glasgow prognostic score (GPS) reflects host systemic inflammatory response and has been reported to be significant as a prognostic indicator in cancer-bearing patients. The aim of this study was to evaluate the predictive value of GPS in outcomes of patients with severe aortic stenosis who were treated with transcatheter aortic valve implantation (TAVI).MethodsThe study population consisted of 79 patients who underwent TAVI due to severe aortic stenosis between January 2018 and March 2019 in our clinic. Echocardiographic and laboratory data were recorded before the procedure and GPS was scored as 0, 1, or 2, based on serum albumin and C-reactive protein levels. European System for Cardiac Operative Risk Evaluation II scoring system was used for risk stratification. The primary endpoints of the study were postoperative in-hospital mortality, hospitalization due to cardiac causes, or mortality within a year.ResultsThe 79 patients were classified into two groups according to outcomes. Fifteen patients (19%) reached the primary endpoints at one year of follow-up. Compared to the patients who did not reach the endpoints, these 15 patients were not different in terms of age, preoperative mean gradient, and ejection fraction (P>0.05 for all). GPS was the only laboratory parameter with statistically significant difference between the groups (P=0.008) and multivariate analysis showed that GPS was independent predictor of primary endpoints (P=0.012, odds ratio 4.51, 95% confidence interval 1.39-14.60).ConclusionGPS is an easy, noninvasive laboratory test which may be used as a predictive biomarker for outcomes in patients undergoing TAVI.
Highlights
The Glasgow prognostic score (GPS) reflects host systemic inflammatory response and has been reported to be significant as a prognostic indicator in cancer-bearing patients
We evaluated the significance of GPS in patients treated with transcatheter aortic valve implantation (TAVI)
One hundred and six patients with severe aortic stenosis that had been treated with TAVI in our clinic between January 2018 and March 2019 were included in this retrospective study
Summary
The Glasgow prognostic score (GPS) reflects host systemic inflammatory response and has been reported to be significant as a prognostic indicator in cancer-bearing patients. The aim of this study was to evaluate the predictive value of GPS in outcomes of patients with severe aortic stenosis who were treated with transcatheter aortic valve implantation (TAVI). Aortic stenosis is one of the most common valve diseases in the worldwide population[1]. It may be clinically asymptomatic for many years, prognosis is poor when the symptoms appear[2]. Transcatheter aortic valve implantation (TAVI) is a new treatment option that is primarily applied in highrisk patients and is suggested to be applied for moderate and low risk afterwards[3]. Lu et al.[4] demonstrated a significant improvement in the valve functions and New York Heart Association classification after TAVI procedure in a small group of patients over 75 years old. In another study by Kocaaslan et al, the increase in quality of life parameters measured with the 36-Item Short Form Survey, or SF-36, in the TAVI group at the end of the 3rd postoperative month was greater than that in the AVR group[5]
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