Abstract
Boosting the birth rate of new neurons in the adult hippocampus is a possible treatment method for the management of Alzheimer's disease (AD). Recent studies have revealed that Ginkgo biloba extract (GBE) can act as a neuroprotective agent to prevent memory loss in a variety of neurodegenerative illnesses. However, the low bioavailability and short half-life of active components in vivo limit their application. Here, we describe a class of microcapsules (MPs) for sustained GBE delivery that have gelatin methacrylate (GelMa) cores and poly(L-lactide-co-glycolide) (PLGA) shells. The encapsulated GBE was slowly released from the solidified MPs during degradation of the polymer. In addition, the MPs showed good biocompatibility in cell experiments. When GelMa-PLGA MPs containing GBE were applied to APP/PS1 mice, amyloid deposition in the mouse brain was reduced, and cognitive impairment was improved. These results indicate that GBE-encapsulated MPs have potential clinical value in treating AD and other neurodegenerative diseases.
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