Abstract
BackgroundThe aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI).MethodsA total of 48 GCF samples from 20 AMI patients, hospitalized at the Department of Cardiology and Angiology of the Johannes Gutenberg University Mainz, were investigated. Besides the myocardial infarction all patients suffered from chronic periodontal disease. Fifty-one GCF samples from 20 healthy age matched individuals with similar periodontal conditions served as controls. The dental examination included the assessment of oral hygiene, gingival inflammation, probing pocket depth, clinical attachment level and X-ray examination. The study was only carried out after the positive consent of the regional ethic commission. A quantitative assessment of aMMP-8 levels in the gingival crevicular fluid was performed with the help of the DentoAnalyzer (Dentognostics GmbH, Jena, Germany), utilising an immunological procedure.ResultsThe aMMP-8 concentrations found in the gingival crevicular fluid of the AMI patients significantly differed (p = 0.001; mean value 30.33 ± 41.99 ng/ml aMMP-8) from the control group (mean value 10.0 ± 10.7 ng/ml aMMP-8). These findings suggest that periodontal inflammation in AMI patients might be associated with higher MMP-8-values compared to the healthy controls.ConclusionsThe acute myocardial infarction seems to influence the degree of periodontal inflammation, thus the measurement of the gingival crevicular fluid MMP8 levels seems to be a helpful biochemical test to obtain information about the severity of the periodontal disease.
Highlights
The aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI)
All patients who were hospitalized on account of an acute myocardial infarction (AMI) suffered from moderate chronic periodontitis
The concentrations of active matrix metalloproteinase-8 (aMMP-8) were significantly elevated in gingival crevicular fluid (GCF) samples from patients after acute myocardial infarction (p = 0.001; median 13.5, mean value 30.33 ± 41.99 ng/ml aMMP-8 eluate) when compared to the GCF samples from the control group (Table 1)
Summary
The aim of this study was to determine the presence of matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after acute myocardial infarction (AMI). The severity of periodontitis can be further quantified by the presence of inflammatory parameters i.e MMPs in the gingival crevicular fluid. This knowledge is helpful for clinicians in finding the most effective treatment modality [1]. Matrix metalloproteinases (MMPs) are a family of enzymes that degrade various components of the extracellular matrix [2,3]. It has been reported that patients with CHD have poorer dental health than controls without CHD [14,15] with periodontitis associated with the development of artherosclerosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
