Abstract
Angiomyofibroblastoma (AMF) is a rare, benign, soft-tissue tumor, which predominantly occurs in the vulvovaginal region of middle-aged women. It is clinically important to distinguish an AMF from other stromal cell lesions. Here, we report the case of a 32-year-old woman with a rare, giant pelvic AMF, which showed a benign clinical course. The tumor was located in the cul-de-sac of Douglas. It was well demarcated, hypocellular, edematous and composed of spindle-shaped and oval stromal cells aggregating around thin-walled blood vessels. The tumor cells had abundant eosinophilic cytoplasm, and expressed estrogen receptors, progesterone receptors and desmin. Mitotic figures were absent. It is important to distinguish AMFs from aggressive angiomyxomas because both occur at similar sites but show different clinical behaviors. Most AMFs and aggressive angiomyxomas have the same immunohistochemical phenotype. The well-circumscribed borders of AMF are the most important characteristic that distinguish it from aggressive angiomyxomas. AMFs rarely recur after complete surgical excision.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5510813471244189.
Highlights
Angiomyofibroblastoma (AMF) is a rare soft-tissue neoplasm that most frequently affects the lower genital tracts of young to middle-aged women
Rare recurrences of AMF after excision have been reported in the literature [6].Here, we report a case of a giant AMF in an uncommon location, namely, the pelvic region
AMF presents as a painless neoplasm located in the superficial regions of the lower female genital tract, such as the vulva and vagina [4], and are detected
Summary
Angiomyofibroblastoma (AMF) is a rare soft-tissue neoplasm that most frequently affects the lower genital tracts of young to middle-aged women. Rare recurrences of AMF after excision have been reported in the literature [6].Here, we report a case of a giant AMF in an uncommon location, namely, the pelvic region. The differential diagnosis for such a tumor includes an aggressive angiomyxoma (AAM), which unlike AMF, does not have well-defined margins.
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