Abstract
Giant cell angiofibroma (GCA) was initially described as a potentially recurrent tumor in the orbit of adults. However, it is now recognized that it can also present in other locations. The morphological hallmark is a richly vascularized patternless spindle cell proliferation containing pseudovascular spaces and floret like multinucleate giant cells. Our case was a 32-years-old female complaining of painless solitary nodule arising on the occipital region of the scalp, which was diagnosed as giant cell angiofibroma. We report the case because of its extremely rare localization.
Highlights
A giant cell rich form of hemangiopericytomas-solitary fibrous tumors (HPC-SFT) was described by Dei Tos as giant cell angiofibroma (GCA) [1]
Mononuclear and multinucleated stromal cells are characteristically positive for vimentin, CD34, CD99 and, less frequently bcl2, but negative for muscle specific actin, desmin, CD31, CD117, S100
It mainly affects infants and children. They are ill-defined, infiltrative masses which composed of hypocellular areas with spindle/giant cells dermatofibrosarcoma protuberans (DFSP)-like storiform areas
Summary
A giant cell rich form of hemangiopericytomas-solitary fibrous tumors (HPC-SFT) was described by Dei Tos as giant cell angiofibroma (GCA) [1]. It shows histologic appearances intermediate between solitary fibrous tumor and giant cell fibroblastoma of soft tissue. Microscopic examination revealed a subcutaneous well-circumscribed mass, consisting of both cellular areas with especially ovalround-to-spindle-shaped cells intermixed with floret like giant cells in a patternless pattern and hypocellular areas together (Figures 1, 2, and 3). Giant cells often lined the pseudovascular spaces.
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