Giant cell angiofibroma of the orbit and eyelid

Abstract

Purpose To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma. Design Observational case series. Main outcome measures Clinical and histopathologic features of giant cell angiofibroma. Methods Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma. Results A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin. Conclusion Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.