Abstract
Peroxisome proliferator-activated receptors γ (PPARγ) is a member of nuclear receptor superfamily, and studies have demonstrated that dysregulation of PPARγ was associated with gestational diabetes mellitus (GDM), which is one of the most common metabolic abnormalities occurring during pregnancy. However, the results regarding the associations between PPARγ and GDM were conflicting among different studies. The present study aimed to determine the expression of PPARγ in adipose and placenta from GDM women in a Chinese population and to further explore the role of PPARγ in GDM women. The adipose and placenta tissues were isolated from GDM women and healthy pregnant women at term. The mRNA and protein expressions of PPARγ in adipose and placenta tissues were determined by qRT-PCR and western blot, respectively. Univariate correlation analysis was used to analyze the relationship between PPARγ expression and clinical characteristics of patients. The levels of tryglycerides and HbA1c were significantly higher, while the levels of low density lipoprotein (LDL) cholesterol, adiponectin and insulin were significantly lower in the GDM women than that in the healthy pregnant women. The mRNA and protein expression of PPARγ in both adipose and placenta from GDM women were significantly lower than that from healthy pregnant women. PPARγ mRNA expression in both adipose and placenta positively correlated with LDL cholesterol and adiponectin levels, and negatively correlated with tryglycerides and glucose levels at 0 h, 1 h and 2 h of 75 g oral glucose tolerance test. In summary, our results suggest that PPARγ may be a key modulator in the development of GDM, due to the roles of PPARγ in glucose homeostasis and adipose tissue development and function.
Highlights
Gestational diabetes mellitus (GDM) is one of the most common metabolic abnormalities occurring during pregnancy, and affects 1% to 14% of all pregnant women depending on ethnic group and the diagnostic test employed [1]
There were www.impactjournals.com/oncotarget no significant differences between healthy pregnant women and gestational diabetes mellitus (GDM) women regarding age, pre-pregnancy body mass index (BMI), pregnancy BMI, body weight gain, gestational age at delivery, fetal weight, total cholesterol, high density lipoprotein (HDL) cholesterol, apoplipoprotein A1, apoplipoprotein B, quantitative insulin sensitivity check index (QUICK-IS)
The levels of tryglycerides and HbA1c were significantly higher in the GDM women than that in the healthy pregnant women; while the levels of low density lipoprotein (LDL) cholesterol, adiponectin and insulin were significantly lower in the GDM women than that in the healthy pregnant women
Summary
Gestational diabetes mellitus (GDM) is one of the most common metabolic abnormalities occurring during pregnancy, and affects 1% to 14% of all pregnant women depending on ethnic group and the diagnostic test employed [1]. GDM is defined as glucose intolerance with onset or first recognition during pregnancy [2]. Studies have demonstrated that GDM was associated with various complications in both mother and newborn. Several factors contributed to GDM have been identified, such as altered plasma adipokine levels, inflammation, deregulation of insulin signaling pathway, oxidative stress [3,4,5,6]. Due to the regulatory roles of peroxisome proliferator-activated receptors γ (PPARγ) in glucose and lipid metabolism, adipocyte differentiation, and inflammation, PPARγ has been shown to be associated with type 2 diabetes mellitus in a large number of www.impactjournals.com/oncotarget
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
