Abstract
Background: Malnutrition is associated with higher risk of mortality in maintenance hemodialysis (MHD) patients. The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. Objectives: The purpose of the present study was to examine the significance of the GNRI as a mortality predictor in MHD patients. Methods: We retrospectively examined the GNRI of 259 MHD patients aged 59.2 ± 12.8 years, and followed up for 36 months. The patients were divided into two groups according to GNRI values of 91.0. Predictors for all-cause mortality were examined using Kaplan-Meier and Cox proportional-hazards analyses. Results: During the follow-up period of 36 months, a total of 76 patients died. Kaplan-Meier survival analysis showed that the subjects with a GNRI 91 (n = 230) (Log-rank test, p < 0.0001). Multivariate Cox proportional-hazards analysis demonstrated that the GNRI was a significant predictor of adjusted all-cause mortality (hazard ratio 0.927; con- fidence interval 0.870 - 0.984, p = 0.013). Conclusion: The results of the present study demon- strate that the GNRI is a strong predictor of all-cause mortality in MHD patients.
Highlights
Protein-energy wasting (PEW) is an important issue in hemodialysis (HD) patients, with a reported prevalenceHow to cite this paper: Takahashi, S., Suzuki, K., Kojima, F., Tanaka, Y. and Nitta, K. (2015) Geriatric Nutritional Risk Index as a Simple Predictor of Mortality in Maintenance Hemodialysis Patients: A Single Center Study
To determine a possible cut-off value of geriatric nutritional risk index (GNRI) for survival, the sensitivity and specificity were examined by receiver operating curve (ROC) analysis
The AUC for GNRI from ROC analysis was 0.673 and the positive likelihood for GNRI was 4.719
Summary
Protein-energy wasting (PEW) is an important issue in hemodialysis (HD) patients, with a reported prevalenceHow to cite this paper: Takahashi, S., Suzuki, K., Kojima, F., Tanaka, Y. and Nitta, K. (2015) Geriatric Nutritional Risk Index as a Simple Predictor of Mortality in Maintenance Hemodialysis Patients: A Single Center Study. (2015) Geriatric Nutritional Risk Index as a Simple Predictor of Mortality in Maintenance Hemodialysis Patients: A Single Center Study. Nutritional risk factor is one of the strong predictors of mortality in HD patients [2] [3]. A clinical assessment of nutritional status is mandatory in HD patients, but there is no single gold-standard method, performed in a reproducible manner and not affected by other confounding conditions. Objectives: The purpose of the present study was to examine the significance of the GNRI as a mortality predictor in MHD patients. Methods: We retrospectively examined the GNRI of 259 MHD patients aged 59.2 ± 12.8 years, and followed up for 36 months. Conclusion: The results of the present study demonstrate that the GNRI is a strong predictor of all-cause mortality in MHD patients
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