Abstract
Geraniol and linalool are major constituents of the essential oils of medicinal plants. Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model. Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800μg/ml and the linalool at concentration of 125μg/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3μg/ml, respectively. Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations.
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