Abstract
Aim: To determine the efficacy of manuka honey against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical strains of Salmonella Typhi. Materials & methods: Clinical isolates were processed using the Bactec blood culture system, identificationand antibiogram by Vitek 2and antibiotic resistance genes through polymerase chain reaction (PCR). Microbroth dilution assays evaluated the antibacterial activity of manuka honey. Results: MDR and XDR-S. Typhi was susceptible to azithromycin. These strains carried the H58, gyrA, gyrB, blaCTX-M-15, and blaTEM-1 genes. At 100% honey, the zone of inhibition for MDR (15-23mm) and XDR (15-24mm) strains. 18/50 MDR and 14/50 XDR strains inhibited at 3.125v/v% killed at 6.25v/v% concentration respectively. Conclusion: Manuka honey could be an alternative option for treating S. Typhi infections.
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