Abstract
Malaria is a serious vector-borne infectious disease in Iran and Anopheles stephensi has long been suspected as a main malaria vector. However, opinions about its vectorial capacity in supporting Plasmodium species and strains are not clear. This study investigates the susceptibility of an Asian main malaria vector, An. stephensi, to Plasmodium vivax isolates, collected from tropical region of Iran. P. vivax gametocytes which used in ex vivo assay to An. stephensi infection were genotyped by using PCR-RFLP and sequencing. A 650-bp fragment was amplified from patients, followed by RFLP analysis using Alu I restriction enzyme determined the presence of P. vivax VK210 variants. Sequence analysis also showed 100% similarity with the previously reported VK210 sequences of haplotype B from Iran. This is the first study that reports An. stephensi mysorensis is susceptible to P. vivax VK210 haplotype, VK210B. This finding help in useful in better understanding the composition and interaction of Anopheles-Plasmodium and its implication in targeting the main malaria vector for control and elimination programs in Eastern Mediterranean region.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.