Abstract
The aim of the study was to identify canine parvovirus type 2 (CPV-2) subtypes circulating among a selected population of domestic dogs and cats in Sri Lanka and to investigate the evolutionary patterns among Sri Lankan viruses in the context of contemporary global CPV-2 sequences. Altogether, 40/61 (65.6%) samples tested were positive for CPV-2 DNA, including 31/48 (64.6%) dogs and 9/13 (69%) cats. All three subtypes (CPV-2a, CPV-2b and CPV-2c) were detected, with CPV-2a being most common. International median joining haplotype network of 291 CPV-2 sequences suggested that there was little barrier for CPV-2 moving between different geographical regions worldwide, including Sri Lanka, and that there was no correlation between the genetic structure within the molecular network and the decade of sample collection. By contrast, there was correlation between CPV-2 subtype and genetic structure, both within the international network and within the network built from 31 Sri Lankan CPV-2 sequences only. The structure within the latter was not correlated with the location of the veterinary clinic where the samples were submitted, the age or species of the host. Altogether, we have shown that there is considerable variability of CPV-2 genotypes circulating in Sri Lanka, which is likely driven by both local evolution and introduction from other countries. The similarity of CPV-2 obtained from cats and dogs suggests that cats may play a role in the epidemiology of CPV-2 in Sri Lanka.
Highlights
Canine parvovirus type 2 (CPV-2) is a small, non-enveloped single stranded DNA virus that is classified within the family Parvoviridae in the species Carnivore protoparvovirus 1 [1]
Canine parvovirus enteritis continues to be an important cause of morbidity and mortality among young dogs worldwide despite the availability of effective vaccines [27,28]
This appears to be true for Sri Lanka, as canine parvovirus type 2 (CPV-2) was detected in feces from nearly 65% of diarrheic dogs tested in the current study
Summary
Canine parvovirus type 2 (CPV-2) is a small, non-enveloped single stranded DNA virus that is classified within the family Parvoviridae in the species Carnivore protoparvovirus 1 [1]. It is extremely stable in the environment; environmental contamination and transmission via fomites are important in the epidemiology of the virus [2]. Its emergence was associated with a pandemic of severe gastroenteritis in domestic dogs worldwide [6]. Parvoviral enteritis is most commonly observed in young, unvaccinated dogs and continues to be an important cause of mortality in such dogs worldwide, including Sri Lanka [8,9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
