Abstract
TheSGKprotein kinase is a novel member of the serine/threonine protein kinase family. Its corresponding gene belongs to the group of immediate-early genes.SGKtranscription is controlled by cell volume alterations in different cell lines. To analyze the genomic structure and chromosomal location of theSGKgene, a human P1 clone was isolated by screening a human genomic library with aSGKcDNA probe. This clone was confirmed to encode the authenticSGKgene by the detection of exon–intron structures and the correspondence between the nucleotide sequences of exons and human cDNA. Using this P1 clone as a probe for fluorescencein situhybridization, a single chromosomal locus forSGKwas assigned to band 6q23, a region frequently affected by deletion in various human neoplasms.
Published Version
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