Genomic epidemiology study of Klebsiella pneumoniae causing bloodstream infections in China.

Xiaoyun Jia ,Yunsong Yu,Rui Zheng,Hong He,Cuidan Li,Gang Li,Hongjie Liang,Xiaofeng Jiang,Bijie Hu,Yan Jin,Ping Ji,Ying Zhu,Fupin Hu,Chao Zhuo,Longhua Hu,Tianshu Sun,Haifeng Shao,Shufang Zhang,Kang Liao,Yingchun Xu,Ziyong Sun,Wenxiang Huang,Qing Yang,Li Gu,Xue Li,Qiong Duan,Fei Chen,Mei Kang,Bin Shu ,Peng Jia

doi:10.1002/ctm2.624

Abstract

Genomic epidemiology study of Klebsiella pneumoniae causing bloodstream infections in China.

Highlights

A total of 239 Kpns were identified by screening 1219 Gram-negative bacteria causing BSI from 24 representative hospitals in different regions of China in 2018 (Table 1 and Figure 1; Table S1 and Figure S1)
Acquired antimicrobial resistance (AMR) gene analysis showed that all 239 strains acquired AMR genes conferring resistance to more than three drug classes (Table S6; Figures S4 and S5)
(82/239, 34.31%)-encoding genes, peg[344] (113/239, 47.28%), rmpA (113/239, 47.28%) and rmpA2 (98/238, 41%), which have been suggested to be the most predictive for hypervirulence,[7] were detected in >30% BSI-Kpns. They were more prevalent in ST23/ST65/K1/K2 (100% in ST23/ST65; 96.3% in K1/K2 except for rmpA2)

Summary

LETTER TO EDITOR

Genomic epidemiology study of Klebsiella pneumoniae causing bloodstream infections in China. Dear Editor, Klebsiella pneumoniae (K. pneumoniae, Kpn) bloodstream infection (BSI) has a considerable prevalence and high mortality worldwide.[1,2,3] The emergence of carbapenemresistant BSI-Kpns, especially those with hypervirulence, poses a challenge for BSI-Kpn control worldwide.[4,5,6] We conducted a large-scale multicenter epidemiological study and in-depth genomic analysis of BSI-Kpns in China, describing a complete molecular epidemiological picture (clinical features, sequence types (STs)/serotypes, antimicrobial resistance/hypervirulence, phenotype/genotype) of BSI-Kpns. A total of 239 Kpns were identified by screening 1219 Gram-negative bacteria causing BSI from 24 representative hospitals in different regions of China in 2018 (Table 1 and Figure 1; Table S1 and Figure S1). Twelve O-loci were detected, O1 and O2 were the most common, together accounting for 79.5% (190/239) of BSI-Kpns (Table 1). The most common carbapenemase was blaKPC-2, varying widely between different STs/serotypes (93.85% [61/65] ST11, 100% [14/14] K47, 86.79% [46/53] K64 strains and 0% of ST23/ST65/K1/K2 strains) (Table S8, Figure S4C).

Other Os

Findings

CONFLICT OF INTEREST