Abstract
Rotavirus A (RVA) G3P[8] is sporadically detected in China, although G9P[8] predominates. To evaluate their genetic composition at the whole-genome level, 24 G3P[8] RVA strains isolated from children under five years were sequenced and characterized. The 24 strains were genotyped as G3-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1, indicating the Wa-like genotype constellation. A maximum clade credibility (MCC) tree for VP7 indicated that G3 had an estimated mean evolutionary rate of 7.279×10-4 substitutions/site/year; thus, 3-5years would pass from the generation of an ancestor virus to the epidemic spread of that virus throughout China. Considering the ongoing prevalence as well as rapid evolution, it is important to monitor G3P[8] RVA epidemics; continuous nationwide surveillance is essential.
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