Genomic Analysis and Molecular Biology of Predatory Prokaryotes

Abstract

Bdellovibrio and Bdellovibrio-like organisms (BALOs) are defined by their unique intraperiplasmic developmental cycle, which is an essential part of their predatory activity on other Gram-negative bacteria. The genome sequence of the type strain of the genus Bdellovibrio is the first of a predatory bacterium to be completed, and will serve as a good model for genomic analysis of predation. Many putative genes have already been identified that could encode products that play important roles in predation. Much work has been done in the past to elucidate the biochemistry and physiology of the BALO predatory life cycle, and the genomic information will permit this wealth of information to be connected with the genetic basis of predation in these unique organisms. As sequence data from other predatory bacteria becomes available, comparative genome analysis will provide important insights into the evolution of genes involved in predatory mechanisms. Clearly, we are on the threshold of a more complete understanding of the BALO developmental cycle, which can serve to increase our understanding of not only predation but also cell–cell interaction. Additionally, the knowledge provided through genome analysis could lead to the potential use of the BALOs as biocontrol, or even biotherapeutic, agents.