Abstract
Genomic Analyses of Clonal Isolates Provide Clues to the Evolution of Streptococcus pneumoniae
Highlights
Until recently, the focus of bacterial genome projects has been individual strains or small numbers of clinical isolates
High levels of recombination have resulted in extreme diversity within pneumococcal populations from which variant genotypes can rapidly emerge in the presence of changing selective pressures
The incidences of invasive pneumococcal disease (IPD) and antibiotic resistant pneumococci decreased dramatically following the introduction of the heptavalent conjugate vaccine PCV7 in 2000 (Dagan, 2009)
Summary
The focus of bacterial genome projects has been individual strains or small numbers of clinical isolates. The first large-scale genomic sequencing project to utilize these technologies for a similar purpose ( by the Bentley group) analyzed 63 clonally related methicillinresistant Staphylococcus aureus isolates (Harris et al, 2010). Croucher et al (2011) analyzed temporally and geographically diverse isolates of a single S. pneumoniae lineage, the multidrug resistant Spain 23F ST81 (PMEN1) pandemic clone, to provide insights into the microevolution of this important pathogen.
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