Genome-Wide Analyses of Hybrid Incompatibility in Drosophila

Kyoichi Sawamura

doi:10.4172/2379-1764.1000159

Abstract

Recent genome-wide analyses accelerate the identification of hybrid incompatibility (HI) genes. Such analyses in the cross between Drosophila melanogaster females and D. simulans males are reviewed here. Number of the HI genes was roughly estimated and some of the HI genes have been molecularly identified. More HI genes will be identified not only in this crossing system but also from diverse organisms in the near future.

Highlights

Recent genome-wide analyses accelerate the identification of hybrid incompatibility (HI) genes
Some genomic regions may be homozygous for alleles from one parental species, and F2 and BC1 viability/fertility seems to be affected by recessive HI genes (Figure 1ii and 1iii)
Male F1 is rescued if a D. simulans mutant of the Lethal hybrid rescue (Lhr) gene [7] or a D. melanogaster mutant of the Hybrid male rescue (Hmr) gene [8] is used for the cross (Figure 2B)

Summary

Introduction

Recent genome-wide analyses accelerate the identification of hybrid incompatibility (HI) genes. F1 viability/fertility seems to be generally affected by dominant HI genes (Figure 1i). Some genomic regions may be homozygous for alleles from one parental species, and F2 and BC1 viability/fertility seems to be affected by recessive HI genes (Figure 1ii and 1iii). The cross between D. melanogaster females and D. simulans males produce only a sterile female F1; male F1 is lethal later at the larval stage (Figure 2A) [6].

Results

Conclusion