Genome-wide association study identifies new loci for albuminuria in the Japanese population

Hiroshi Okuda,Koji Okamoto,Kozo Tanno,Makoto Sasaki,Masayuki Yamamoto,Satoshi Makino,Kota Ishizawa,Michiaki Abe,Sadayoshi Ito,Atsushi Hozawa,Tadashi Ishii,Junichi Sugawara,Gen Tamiya,Osamu Tanabe

doi:10.1007/s10157-020-01884-x

Abstract

BackgroundUrinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population.MethodsWe conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS.ResultsEighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10−10)].ConclusionIn this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.

Highlights

Chronic kidney disease (CKD) is one of the most severe global public health problems [1]
While a few genome-wide association studies (GWAS) on Urinary albumin excretion (UAE) have been conducted in individuals with type 2 diabetes mellitus [9] and type 1 diabetes mellitus [10] in European ancestral cohorts [11,12,13], there is no such GWAS conducted in the Asian population
We have conducted GWAS using health-survey data collected in the Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM) to identify the several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population

Summary

Introduction

Chronic kidney disease (CKD) is one of the most severe global public health problems [1]. We have conducted GWAS using health-survey data collected in the Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM) to identify the several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. A few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. We conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. Methods We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM).

Methods

Results

Conclusion