Abstract
We have resequenced the genomes of four Burkholderia pseudomallei K96243 laboratory cultures and compared them to the reported genome sequence that was published in 2004. Compared with the reference genome, these laboratory cultures harbored up to 42 single-nucleotide variants and up to 11 indels, including a 31.7-kb deletion in one culture.
Highlights
Burkholderia pseudomallei causes melioidosis, a bacterial disease of humans and animals [1]
At 21 sites, the same single-nucleotide variants (SNVs) was present in all resequenced cultures, suggesting errors in the reference genome
9 11 9 9 a SNVs and indels are in comparison to the K96243 genome sequences in GenBank
Summary
Titballa aBiosciences, University of Exeter, Devon, United Kingdom bDefence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom cLondon School of Hygiene & Tropical Medicine, London, United Kingdom
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