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Cite Journal: Haematologica |  Publication Date: Jul 18, 2008 |
 Citations: 7 |  License type: publisher-specific license |
The germinal center reaction is integral to B-cell maturation, where class switch recombination (CSR) and somatic hypermutation (SHM) are targeted to the immunoglobulin (Ig) locus to facilitate antibody diversity.[1][1] Selection against B cells with auto-reactive or low affinity antigen receptors
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