Abstract
BackgroundPatients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies.Methods and resultsWe examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76).ConclusionsWe demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.Electronic supplementary materialThe online version of this article (doi:10.1186/2045-3701-4-67) contains supplementary material, which is available to authorized users.
Highlights
Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication
We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and Intravenous immunoglobulin (IVIG) used time, and may serve as a genetic marker for the CAA formation in KD
No significant differences were found between these 2 groups, suggesting that the glutamate receptor family genes may not contribute to KD susceptibility
Summary
Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Patients with Kawasaki disease (KD), an acute systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. Infectious agents, host immune dysregulation, and genetic susceptibility are thought to be responsible for the development of KD and its related complications [1,2,3]. Numerous genome-wide association studies have been conducted to identify host cellular genes that affect KD susceptibility [4,5,6,7,8,9,10,11,12,13,14] in the European, Japanese, Korean, and Taiwanese populations.
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