Abstract
Objectives. The present study aimed to evaluate the effect of CD40 and CXCR4 genes polymorphisms on CAD susceptibility and the blood lipid levels and history of cardiovascular risk factors in a Chinese Han population. Materials and Methods. A total of 583 unrelated patients with CAD and 540 controls were recruited. Two tag SNPs (rs4239702 and rs1535045) at the CD40 locus and one tag SNP (rs2228014) at the CXCR4 locus were genotyped using the SEQUENOM Mass-ARRAY system. Results. After adjusting the risk factors, the frequency of rs1535045-T allele was also higher in patients than controls. Haplotype analysis showed that the rs4239702(C)-rs1535045(T) haplotype was associated with CAD. People with rs4239702-TT genotype had higher blood lipid levels in case group while it was not in the control group. History of cardiovascular risk factors showed no association for the three SNPs in case group and control group. Conclusions. rs1535045 in CD40 gene is likely to be associated with CAD in the Chinese Han population. rs4239702(C)-rs1535045(T) haplotype was associated with CAD. Only in CAD patients, the blood lipid level of patients with rs4239702-TT genotype was higher than other patients. CXCR4 gene may not relate to CAD.
Highlights
Coronary artery disease (CAD) is a complex disease and it has become the leading cause of death of human diseases worldwide [1,2,3,4]
There was no significant difference in the mean age, sex, body mass index (BMI), total cholesterol (TC), and TG
The frequency of rs1535045-T allele was higher in patients than controls (OR = 1.21, 95% confidence intervals (CIs) 1.01–1.45, P < 0.05); after adjusting the risk factors, the odds ratios (ORs) is 1.27
Summary
Coronary artery disease (CAD) is a complex disease and it has become the leading cause of death of human diseases worldwide [1,2,3,4]. There is no doubt that a genetic factor, which accounted for 30%∼60% of the risk of CAD [5, 6], and the traditional risk factors, such as age, male gender, smoking, drinking, obesity, hypertension, hypercholesterolemia, and diabetes mellitus, contribute to the pathogenesis of CAD. Vascular function is an important pathophysiological factor in cardiovascular diseases, and is influenced by many factors. Evidence suggested that inflammation may be a risk factor for CAD [7]. Inflammation in the vessel wall plays an essential role in the initiation and progression of the atherosclerotic lesion, and in the destabilization and acute rupture of plaques that occur during acute myocardial ischemic events [8,9,10]. Atherosclerotic lesion and acute myocardial ischemia share the same mechanism with CAD
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