Abstract
PurposeToll-like receptor 4 (TLR4) is known to be involved in innate immunity and inflammatory responses that play important roles in the pathogenesis of coronary artery disease (CAD). But the relationship between TLR4 gene and CAD has yet to be investigated. The present study aimed to evaluate the association of TLR4 gene polymorphisms with CAD susceptibility in a Chinese Han population.MethodsA total of 1094 subjects (577 unrelated patients with CAD and 517 controls) were recruited between 2008 and 2012. Three tag SNPs (rs1927907, rs1927911 and rs11536889) present in the TLR4 gene were genotyped using Sequenom Mass-ARRAY system.ResultsThe genotypic distributions of the three SNPs were not deviate from Hardy–Weinberg equilibrium. There was no significant difference in distributions of allelic frequencies of each SNPs between healthy controls and CAD patients (P > 0.05). Genotype frequencies of TLR4 gene did not show any statistically significant difference between the two groups in co-dominant, dominant or recessive genetic models (P > 0.05). The frequency of haplotypes in the case group was similar to that in the control group (P > 0.05).ConclusionTLR4 gene do not relate to genetic susceptibility of CAD in the Chinese Han population.
Highlights
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide (Roger et al 2012)
Toll-like receptors (TLRs) are a group of pathogenassociated molecular pattern receptors involved in innate immunity and pathogen recognition
236 (21.2) 0.420 0.517 427 (38.3) 0.014 0.907 279 (25.0) 0.575 0.449 166 (14.9) 0.088 0.767 systemic analysis, we found no evidence to support a significant association between Toll-like receptor 4 (TLR4) gene polymorphisms and CAD susceptibility
Summary
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide (Roger et al 2012). The main pathological features of CAD are atherosclerotic changes, which include vascular endothelial damage, adhesion and migration of monocytes, lipid accumulation in macrophages, and the formation of foam cells (Fredman and Spite 2013). Activation of innate immunity system and chronic low-grade inflammation play important roles in. Toll-like receptors (TLRs) are a group of pathogenassociated molecular pattern receptors involved in innate immunity and pathogen recognition. TLR4 can ligate with the exogenous ligand lipopolysaccharide, in particular from gram-negative bacteria, and several endogenous ligands, such as endogenous molecules released by injured tissues and necrotic cells. These molecules, called damage-associated molecular pattern molecules, induce the activation of a strong proinflammatory
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