Association between single nucleotide polymorphisms of vascular endothelial growth factor gene and coronary artery disease susceptibility

Abstract

Objective To study the association between 10 single nucleotide polymorphisms (SNP)of the vascular endothelial growth factor gene(VEGF)and the risk of coronary artery disease (CAD). Methods We examined the potential association between CAD and 10 single nucleotide polymorphisms(SNP, rs699947, rs1570360, rs2010963, rs833068, rs3024997, rs3025000, rs3025010, rs3025020, rs3025030 and rs3025039) of the VEGF gene using the Mass ARRAY system.Participants included 242 CAD patients and 253 healthy controls from a Chinese Han Population. Results The CAD patients had significantly higher frequency of the rs699947 A allele[27. 3% vs.18. 4%, χ2= 11. 141,P< 0. 01, odds ratio(OR)= 1. 665, 95% confidence interval(CI): 1. 232-2. 250] and rs2010963 C allele(47. 9% vs.36. 4%,χ2= 13. 593,P< 0. 01,OR= 1. 611,95% CI: 1. 249-2. 077). Conclusion These findings point to a role for VEGF polymorphism in CAD in a Chinese Han population, and may be informative for future investigations on the pathogenesis of CAD. Key words: Coronary artery disease; Vascular endothelial growth factor; Single nucleotide polymorphisms