Abstract
To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma (P(trend)<0.05) in six genes (IL1RN, IL2, IL12RB1, JAK3, TNFRSF13B, and XRCC3). The most significant association was seen for IL2 variant rs2069762 (OR(TG+GG) vs. TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005). These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma.
Highlights
Lymphoma is the third most common cancer of children around the world (Howlader et al, 2011)
These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma
Some studies have reported single nucleotide polymorphisms (SNPs) associated with lymphoma, there are a few studies about immune response, apoptosis, cell cycle and DNA repair genes aimed among children
Summary
Lymphoma is the third most common cancer of children around the world (Howlader et al, 2011). It is known that immune system disorders are main causes of lymphoma, little is known regarding genetic factors involved in the immune system but in others like apoptosis, cell cycle, DNA repair (Seidemann et al, 2005). Some studies have reported SNPs associated with lymphoma, there are a few studies about immune response, apoptosis, cell cycle and DNA repair genes aimed among children. We hypothesized that gene variations of immune response and DNA repair gene may affect childhood lymphoma risk. In order to estimate the genetic susceptibility for childhood lymphoma, we conducted an association study using 1536 SNPs selected in 138 candidate gene regions related to immune response, apoptosis, cell cycle, and DNA repair among Korean children
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