Abstract 2765: Genetic variants in immunoregulaion and DNA repair related genes and risk of lymphoma among children in Korea

Abstract

Abstract Although lymphoma is recognized as a cancer of the immune system, little is known regarding a role for genes involved immune system. Genetic susceptibility studies of lymphoma may serve to identify at risk populations and to elucidate important disease mechanisms. In order to estimate the genetic susceptibility for childhood lymphoma, we investigated whether genetic variation 1536 tag single nucleotide polymorphisms (SNPs) selected in 138 candidate gene regions related to immune response, apoptosis, cell cycle, and DNA repair. We used the GoldenGate (Illumina) oligonucleotide pool assay (OPA) in 40 cases patients and 254 controls among Korean children. The association study was estimated as odds ratios and 95% confidence intervals adjusted for age. The minP test was used to identify statistically significant association at gene level. Five genes (IL1RA, IL2, IL12RB1, JAK3, and TNFRSF13B) in immune response and one gene (XRCC3) in DNA repair had statistical significance (minP < 0.05). In these regions, total twelve SNPs (rs11677140, rs10857092, rs2069762, rs4833248, rs365179, rs3212701, rs3212711, rs7250423, rs3751987, rs3751991, rs4343329, rs861547) were significantly associated the risk of lymphoma (Ptrend < 0.05). The most significant association with the risk of lymphoma was seen for IL2 rs2069762 (ORCC/AA = 10.1, 95% CI = 2.4-43.1, Ptrend = 0.002, minP = 0.005). These findings suggest that common genetic variants in immune response and DNA repair related genes might play a role in the genesis of childhood lymphoma with limited biological evidence. Additional larger studies are needed to identify these findings and understand the mechanisms of these genes in childhood lymphoma patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2765. doi:10.1158/1538-7445.AM2011-2765