Abstract
The single nucleotide polymorphism (SNP) rs2910164 G>C within miR-146a has been reported that is associated with the increased risk of gastric cancer (GCa). However, the results are inconclusive, espicially among Asian populations, which probably due to small sample size in each single study. To validate this association and get a more precise estimation, we conducted a large GCa study including 1,125 cases and 1,196 controls in an eastern Chinese population. Our results showed that this SNP was not associated with GCa risk in either of the three genetic models [co-dominant model: CG vs. CC, odds ratio (OR) = 0.99, 95% confidence interval (95%CI): 0.83-1.19; GG vs. CC, OR = 1.03, 95%CI: 0.81-1.32; dominant model: (CG+GG) vs. CC, OR = 1.00, 95%CI = 0.84-1.19; recessive model: GG vs. (CG+CC), OR = 1.04, 95%CI = 0.83-1.29]. Stratified analysis by age, gender, smoking status, drinking status, or tumor location confirmed this non-significant association. In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population. Larger and well-designed, preferably prospective studies are needed to further confirm our findings.
Highlights
In China, Gastric cancer (GCa) is the second most common cancer, with an estimated 679,100 new GCa cases and 498,000 deaths in 2015, accounting for 15.8% of the cancer cases and 17.7% of cancer deaths, respectively [1].the underlying mechanism of its carcinogenesis is still not fully understood
The single nucleotide polymorphism (SNP) rs2910164 G>C has been reported which is associated with the increased risk of GCa [21, 22]
We conducted a large GCa study of 1,125 cases and 1,196 controls in a wellestablished gastric cancer study cohort to validate this association in an eastern Chinese population
Summary
In China, Gastric cancer (GCa) is the second most common cancer, with an estimated 679,100 new GCa cases and 498,000 deaths in 2015, accounting for 15.8% of the cancer cases and 17.7% of cancer deaths, respectively [1].the underlying mechanism of its carcinogenesis is still not fully understood. MiRNA, a small non-coding RNA molecule consisting of ~22 nucleotides, has crucial biological functions in post-transcriptional regulation of genes, as well as cell differentiation, proliferation, and apoptosis [9,10,11,12]. All these functions have critical roles in the development of cancer, including gastric cancer [13, 14]. We conducted a large GCa study of 1,125 cases and 1,196 controls in a wellestablished gastric cancer study cohort to validate this association in an eastern Chinese population
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