Abstract
SALATRIM triacylglycerols differ from other fats in their ratio of short-chain fatty acids to long-chain fatty acids and in that the predominant long-chain fatty acid is stearic acid. Caloric availability studies in rats indicate SALATRIM fats yield 4.5-6 kcal/g compared to 9.0 kcal/g to for corn oil. Structure/ activity relationships predict SALATRIM would have no mutagenicity in the Salmonella/microsome reverse mutation assay (Ames assay). To test this hypothesis, the mutagenic potential of six SALATRIM fats, at doses as high a 1000 microgram/plate, was determined using five Salmonella strains with and without metabolic activation. Concurrent positive control compounds produced the expected positive responses. Corn oil and solvent controls were negative. SALATRIM fats were without cytotoxic and mutagenic potential in the five tester strains with and without metabolic activation. The hypothesis that SALATRIM triacylglycerols are not mutagenic based upon structure/activity relationships was confirmed.
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