Abstract
The SALATRIM family of triacylglycerols differs from other fats in the ratio of short-chain fatty acids (SCFA) to long-chain fatty acids (LCFA) and in that stearic acid is the major LCFA. These fats have caloric availability values (4.5-6 kcal/g) lower than that of corn oil (9 kcal/g). SALATRIM 23CA Lot A014, a typical SALATRIM fat, was tested in vitro mammalian cell genotoxicity assays including the chromosomal aberration, unscheduled DNA synthesis, and HPRT mammalian cell mutagenesis assays. Corn oil also was tested as a reference fat. Both the SALATRIM fat and corn oil were negative in the three assays. SALATRIM 234CA lot A019 and SALATRIM 234CS lot A018 were tested in the in vivo bone marrow micronucleus assay. Rats received these SALATRIM fats or corn oil at 10 % (w/w) in the diet for 13 weeks. Both fats were negative in this assay. The data confirm the prediction that SALATRIM fats lack genotoxic potential.
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