Genetic study via chromosomal aberration for induced obesity in male albino mice

Abstract

AimsObesity is induced by a high-calorie diet that contributes to genomic instability. This study aimed to better understand the impact of high-calorie diets on chromosomal aberration. Design & methodsThe present study consisted of 32 male albino mice were randomly divided into four equal groups: control diet, high-fat diet, high-sucrose diet, and high fat-sucrose diet groups. Chromosomal aberration was detected by cytogenetic studies. ResultsOur results showed that there was a highly significant structural-numerical chromosomal aberrations in the studied obese groups compared to the control group (P < 0.05). Also, glucose, cholesterol, and triglyceride levels were significantly elevated in the obese groups compared to controls (P < 0.01). ConclusionsWe suggested that environmental factors such as a high-calorie diet leading to obesity causes epigenetic alterations through the susceptibility to genome instability as shown in the chromosomal aberrations, besides disruption in carbohydrate and lipid metabolism as evidenced by increased levels of glucose and lipid profile in male mice. These findings have significant implications for preventing and treating obesity-related diseases, as they highlight the importance of promoting a healthy lifestyle and diet to reduce the risk of epigenetic changes.