Genetic studies of free‐ranging macaques of Cayo Santiago II. 6‐Phosphogluconate dehydrogenase and NADH‐methemoglobin reductase (NADH‐diaphorase)

Abstract

AbstractFor the population of 395 semi‐free‐ranging rhesus macaques (Macaca mulatta) that inhabited Cayo Santiago in 1976, 6‐phosphogluconate dehydrogenase phenotypes of 378 animals were determined. Three phenotypes, controlled by two autosomal codominant alleles,PGDA andPGDB, were found by electrophoretic methods. The frequencies of the alleles are 0.898 and 0.102, respectively. The population, composed of five troops and peripheral males, is in Hardy‐Weinberg equilibrium at this locus. The allele frequencies at the 6‐phosphogluconate dehydrogenase locus in the population in 1976 were compared with frequencies in 1973; a statistically significant difference was found in one troop. The phenotypes of NADH‐methemoglobin reductase (NADH‐diaphorase) were determined electrophoretically for 372 animals. These phenotypes are probably the products of two autosomal codominant alleles,Dia1 andDia2, with frequencies of 0.786 and 0.214, respectively. The population is in equilibrium at this locus also. Tests of homogeneity at the dehydrogenase and reductase loci indicate that the allele frequencies are significantly different among the five troops in the population. Observed and expected phenotypic ratios in progeny were compared at the dehydrogenase and the reductase loci. The only significant deviation from expectation occurs among offspring of mothers heterozygous at the reductase locus. The observed distributions of alleles at the 6‐phosphogluconate dehydrogenase locus and the NADH‐methemoglobin reductase locus are probably the results of stochastic processes.