Abstract
Introduction: About 30% of the general population manifests periodontal disease (PD). Patients with parents with a compromised periodontal condition may need prosthetic or implantology treatment (PIT), therefore those patients are at increased risk of developing PD during or after dental treatment. Hence the use of a genetic test for identify those most at risk of PD and submit them to very closely oral hygiene protocols, is mandatory. PIT of these patients must be done safely having previously assessed the risk of developing PD. Polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, so the use of a genetic test is fundamental to ensure a correct preventive protocol and plaque control in healthy patients.
Highlights
Young patients with parents with a compromised periodontal condition may need prosthetic or implantology treatment (PIT), these patients are at increased risk of developing periodontal disease (PD) during their life
We reported a statistical significant association between common variant alleles, IL6 rs1800795-G and IL 10 rs1800872-A, and periodontal disease. These data suggest a possible use of these polymorphism in a DNA-based diagnostic test of periodontitis
Implantology and prosthetic rehabilitation is a part of forensic litigation in dentistry, though prevent PD is mandatory for dentist
Summary
Young patients with parents with a compromised periodontal condition may need prosthetic or implantology treatment (PIT), these patients are at increased risk of developing PD during their life. Infact they must be considered “healthy” people, because they don’t manifest clinical signs of PD, but they could be at major risk to develop PD. Oral hygiene may be more difficult to maintain after PIT, which may lead to plaque accumulation and inflammation. Both favorable and unfavorable periodontal outcomes seem possible after PIT. Our group has performed a genetic test aimed at identifying a possible genetic predisposition to the onset of periodontal disease in each patient, and in particular in patients whose parents had PD
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