Year-end Sale % OFF 
Abstract
High myopia is an ophthalmic pathology that affects half of the young adults in the United States and Europe and it is predicted that a third of the world’s population could be nearsighted at the end of this decade. It is characterized by at least 6 diopters or axial length > 26 mm and, choroidal neovascularization (CNV) in 5 to 11% of cases. Ranibizumab is a recombinant humanized monoclonal antibody fragment. It is an anti-vascular endothelial growth factor (anti-VEGF) drug used in the treatment of CNV. Many genetic polymorphisms have been associated with interindividual differences in the response to ranibizumab, but these associations were not yet assessed among patients with high myopia and CNV. We performed a retrospective study assessing the association of genetic polymorphisms with response to ranibizumab in patients with CNV secondary to high myopia (mCNV). We included genetic polymorphisms previously associated with the response to drugs used in CNV patients (bevacizumab, ranibizumab, aflibercept, and photodynamic therapy (PDT)). We also included genetic variants in the VEGFA gene. Based on our results, ARMS2 (rs10490924) and CFH (rs1061170) are associated with response to ranibizumab in high myopia patients; and, included VEGFA genetic polymorphisms are not associated with ranibizumab response in our population but might be related to a higher risk of CNV.
Highlights
Myopia is a pathology in which the image is cast in front of the retina instead of on it.It happens because the eyeball is too elongated, or in a minority of cases because of the increasing refractive index of the crystalline in nuclear cataract or cornea in keratoconus [1].Myopia noted a rise worldwide over time
To include genetic variants that could affect the response that patients have to ranibizumab, we considered including genetic variants that had been previously associated with the response to treatments used in patients with high myopia and choroidal neovascularization (CNV), if this association had been found in patients with any ophthalmic pathology
At 6-months follow-up (Table 4B), we found that ARMS2 G allele is associated with increased best-corrected visual acuity (BCVA) improvement (OR = 1.95; 95%CI = 0.98–3.83; p = 0.037)
Summary
Myopia is a pathology in which the image is cast in front of the retina instead of on it.It happens because the eyeball is too elongated, or in a minority of cases because of the increasing refractive index of the crystalline in nuclear cataract or cornea in keratoconus [1].Myopia noted a rise worldwide over time. Myopia is a pathology in which the image is cast in front of the retina instead of on it. It happens because the eyeball is too elongated, or in a minority of cases because of the increasing refractive index of the crystalline in nuclear cataract or cornea in keratoconus [1]. Myopia noted a rise worldwide over time. It affects about half of young adults in the United States and Europe, and it is even more prevalent in Asia. It has twice the prevalence compared to 50 years ago, and it is forecast that a third of the world’s population will be nearsighted at the end of this decade [2].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
