Abstract
Objective of investigation: to study the role of Toll-like receptor 4 Asp299Gly gene polymorphism in the implementation of susceptibility to chronic pyelonephritis, to analyze its association with the major manifestations of the disease and to assess the impact on the synthesis of interleukin-6 in the blood of sick children.Methods. We examined a group of children aged 1–15 years with chronic pyelonephritis in the active stage (n = 60). Control group consisted of 95 apparently healthy people. Results. There were revealed significantly higher prevalence of Toll-like receptor 4 Asp299Gly gene polymorphism among children with chronic pyelonephritis (n = 60), identified a statistically significant correlation of mutant genotypes Asp299Gly, Gly299Gly with manifestation of the disease before the age of 3, and frequent episodes of acute respiratory viral infections, torpid urinary syndrome, unstable remission and increased secretion of interleukin-6 (p < 0.001). Thus, genetically determined Toll-like receptor 4 Asp299Gly gene polymorphism is a marker of high risk of early manifestation of chronic inflammation in the kidney interstitium and prolonged recurrent clinical course of the disease in children.
Highlights
A clinical and laboratory examination of 60 children aged between 1–15 years with chronic pyelonephritis who were hospitalized in the pediatric ward No 2, Poltava Regional Children Clinical Hospital
The study of the prevalence of normal and mutant alleles of the gene 299Gly Toll-like receptor 4 in the surveyed groups (Table 2) showed that the mutant allele Gly more than 4 times frequently detected among children with chronic pyelonephritis (7.5 %) compared with the control group (1.58 %) ( 2 = 4.576; odds ratio (OR) = 1.059, confidence interval (CI) = 0.9989–1.122, p = 0.049)
As part of our work is an important step was to investigate the influence of single nucleotide polymorphisms Asp299Gly TLR4 gene on the course and characteristics of clinical manifestations of chronic pyelonephritis in children
Summary
Objective of investigation: to study the role of Toll-like receptor 4 Asp299Gly gene polymorphism in the implementation of susceptibility to chronic pyelonephritis, to analyze its association with the major manifestations of the disease and to assess the impact on the synthesis of interleukin-6 in the blood of sick children. Genetically determined Toll-like receptor 4 Asp299Gly gene polymorphism is a marker of high risk of early manifestation of chronic inflammation in the kidney interstitium and prolonged recurrent clinical course of the disease in children. The aim of our research has included studies the role of gene polymorphisms Asp299Gly TLR4 in the implementation of susceptibility to chronic pyelonephritis, analyze its association with major manifestations of the disease and to evaluate the impact on the synthesis of IL-6
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