Genetic Polymorphism of lipoprotein lipase, Beta 3 Adrenergic Receptor and Plasma Cell Membrane Glycoprotein and The Susceptibility to Dyslipidemia

Abstract

BackgroundDyslipidemia is one of the most common disorders in the modern society to the extent that it is the major determinant of the degree of excessive morbidity and mortality.AimIdentification of subject at risk of dyslipidemia in order to carry more effective interventions to prevent the development or progression of the associated complication such as cardiovascular diseases.Material and MethodsThe study group consisted of 202 individual with different lipid profiles. Individuals were genotyped for LPL Hind III, LPL S447X, β 3 ADR and PC1 by using PCR‐RFLP. Statistical analysis was done by using SPSS program.ResultsCarriers of H+/H+ genotype were at significant high risk of developing dyslipidemia manifested by high triglycerides, high LDL and low HDL (OR=1.9, 2.3 and 2.0) respectively. SS genotype was associated with significant increase risk of total cholesterol (OR= 2.7). C allele of β 3 ADR was a risk factor for low level HDL (OR= 2.3). Carriers of Q allele of PC1 were at significant risk of developing atherogenic phenotype manifested by low level HDL and high level LDL (OR=2.4 and 5.1) respectively. Furthermore combined analysis revealed that carrier of two or more of the previous haplotypes were at the highest risk of developing dyslipidemia.ConclusionH+, S, C and Q alleles were risk factors of developing atherogenic lipid profile.Source of fund: Ain Shams University.