Abstract
Not only is alcoholism one of the world’s major public health problems because of the significant morbidity caused by alcohol abuse disorder but it is also a big social problem. An atypical allele (ALDH2∗487Lys, former name ALDH2∗2) in low Km aldehyde dehydrogenase (ALDH2), which is highly prevalent in Asian populations, is associated with drinking behavior and some alcohol-related diseases (Yoshida, 1994; Yokoyama et al., 2003). There are some differences in its frequency among Asian populations of different geographic areas. In our previous study, the frequency of the ALDH2∗487Lys allele was much lower (12%) in Wuhan Han Chinese and much higher (31%) in Guangdong Han Chinese populations than that reported in other Oriental populations (Chen et al., 1999; Luo et al., 2001; Luo and Zhang, 2004). Recent developments in gene therapy allow a long-term inhibition of gene expression. Garver et al. (2001) asserted that antisense oligonucleotides
Published Version
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